Predicting ATP-Binding Cassette Transporters Using the Random Forest Method
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چکیده
منابع مشابه
ATP-binding cassette transporters, atherosclerosis, and inflammation.
Although recent genome-wide association studies have called into question the causal relationship between high-density lipoprotein (HDL) cholesterol levels and cardiovascular disease, ongoing research in animals and cells has produced increasing evidence that cholesterol efflux pathways mediated by ATP-binding cassette (ABC) transporters and HDL suppress atherosclerosis. These differing perspec...
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A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol levels have major impacts on initiation, progression, and regression of CVD. Four members of the ATP-binding cassette (ABC) transporter family play important roles in this modulation. ABCA1 and ABCG1 export excess cellula...
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The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has bee...
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Till date the largest known family of transporters is ABC transporter superfamily. The genes that encode ABC genes are widely dispersed in genome and show a high degree of amino acid sequence identity among eukaryotes. Phylogenetic analysis has allowed the gene superfamily divided into seven subfamilies containing 49 members of proteins in human. Despite the immense amount of biochemical studie...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2020
ISSN: 1664-8021
DOI: 10.3389/fgene.2020.00156